Symbol
Name
ID

Braf
Braf transforming gene
MGI:88190

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes

Abnormal esophagus morphology

Hereditary nonpolyposis colorectal carcinoma

Colon cancer

Intestinal pseudo-obstruction

Neoplasm of the stomach

Constipation

Intermittent diarrhea

Nausea and vomiting

Vomiting

Functional abnormality of the gastrointestinal tract

Dysphagia

Impaired oropharyngeal swallow response

Gastroesophageal reflux

Functional intestinal obstruction

Neoplasm of the liver

Abnormality of the gastrointestinal tract

Disease(s) Associated with BRAF

cardiofaciocutaneous syndrome

cardiofaciocutaneous syndrome 1

colorectal cancer

Noonan syndrome 7

pancreatic cancer

Mouse Phenotypes

abnormal pancreatic acinar cell morphology

abnormal intestinal epithelium morphology

abnormal intestinal mucosa morphology

abnormal crypts of Lieberkuhn morphology

abnormal large intestine crypts of Lieberkuhn morphology

abnormal large intestine morphology

increased large intestine length

abnormal small intestine morphology

abnormal small intestinal villus morphology

branched small intestinal villi

increased small intestine length

intestine polyps

increased gastrointestinal tumor incidence

increased intestinal adenoma incidence

Availability

Mouse Genotype

Braf^tm1Bbd/Braf⁺

Braf^tm1.1Brd/Braf⁺
Tg(Vil1-cre)997Gum/0 (conditional)

Braf^tm2Cpri/Braf⁺
Tg(CMV-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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